Synthesis and antimicrobial properties of novel 2,5-disubstituted 1,3,4-oxadiazoles
نویسندگان
چکیده
The search for better antimicrobial agent due to rapid appearance of multidrug resistant microorganism and antimicrobial properties of semicarbazones and 2,5-disubstituted 1,3,4-oxadiazoles prompted us to undertake the synthesis of a few novel N-[5-(4-substitutedphenyl)-1,3,4-oxadiazol-2-yl]-N-(4substitutedbenzaldehyde)-semicarbazone and N-[5-(4-substitutedphenyl)-1,3,4-oxadiazol-2-yl]-N-[1-(4substitutedphenyl)ethanone]-semicarbazone hitherto unreported for their antimicrobial activity. The structures of the compounds were elucidated by elemental and spectral (IR, H NMR, C NMR and MS) analysis. The antimicrobial potential of the compounds was investigated using disk diffusion method. Compound VI(o) was found to possess significant antimicrobial activity during antimicrobial evaluation. Compound VI(m), VI(n) and VI(p) also demonstrated marked antimicrobial property. Structure-activity relationships among synthesized compounds were also established.
منابع مشابه
Synthesis and antimicrobial evaluation of some 2,5 disubstituted 1,3,4-oxadiazole derivatives
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GABRIELA LAURA ALMAJAN1*, STEFANIA-FELICIA BARBUCEANU1, ILEANA FARCASANU2, CONSTANTIN DRAGHICI3 1 University of Medicine and Pharmacy, Faculty of Pharmacy, Organic Chemistry Department, 6 Traian Vuia Street, 020956 Bucharest, Romania 2 University of Bucharest, Faculty of Chemistry, Organic Chemistry, Biochemistry and Catalysis Department, 90-92 Sos. Panduri, 050663, Bucharest, Romania 3 Romania...
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